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Mas-Related G Protein-Coupled Receptor Member D Sustains Hypertension
Kun Zhao1, Dongxu Hua1, Yukang Mao1
1Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu Province China.
Medcomm
|April 3, 2026
Summary
Mas-related G protein-coupled receptor member D (MrgD) drives hypertension and vascular remodeling. Inhibiting MrgD with risperidone offers a potential treatment for high blood pressure and related vascular issues.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Pharmacology
Background:
- Hypertension and vascular remodeling are significant global health concerns.
- The precise role of Mas-related G protein-coupled receptor member D (MrgD) in hypertension is not fully elucidated.
Purpose of the Study:
- To investigate the role of MrgD in the pathogenesis of hypertension and vascular remodeling.
- To identify potential therapeutic targets for hypertension.
Main Methods:
- Analysis of MrgD expression in hypertensive patients and animal models.
- Genetic manipulation of MrgD in rat and mouse models of hypertension.
- Mechanistic studies involving vascular smooth muscle cells (VSMCs) and signaling pathways.
- Identification of MrgD inhibitors using artificial intelligence and functional validation.
Main Results:
- MrgD expression is upregulated in hypertension.
- MrgD overexpression exacerbates hypertension and vascular remodeling; MrgD knockdown ameliorates these effects.
- MrgD mediates vascular remodeling via the Cav1.2-CaMKIIγ signaling axis, enhanced by Ang II.
- Risperidone identified as an MrgD inhibitor that reduces hypertension and vascular remodeling.
Conclusions:
- MrgD is a key factor in hypertension development and vascular complications.
- Targeting MrgD presents a promising therapeutic strategy for managing hypertension.
Keywords:
Ca2+/calmodulin‐dependent protein kinase II (CaMKII)Mas‐related G protein‐coupled receptor member D (MrgD)artery remodelinghypertensionvoltage‐gated L‐type Ca2+ channel (Cav1.2)More Related Videos
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