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Updated: Apr 4, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
[Study on the regulation mechanism of IL-17 signaling pathway and its intervention strategy in inflammatory diseases]
Yang Liu1, Yingying Chen1, Ziru Wei1
1Department of Otolaryngology Head and Neck Surgery, Binzhou Medical University Hospital, Binzhou 256603, China.
Abstract:
The interleukin 17 (IL-17) signaling pathway plays a crucial role in the pathogenesis of various inflammation-related diseases and tumours. The IL-17 family of cytokines, particularly IL-17A, has been extensively studied, revealing its pro-inflammatory effects and dual-role in immune responses. Recent studies have shown that IL-17 not only promotes the progression of autoimmune diseases such as psoriasis and ankylosing spondylitis but also facilitates tumour development by regulating immune escape mechanisms within the tumour microenvironment. Although therapeutic strategies targeting IL-17 have shown promising clinical potential, the differences in their effects across various patients and disease states require further investigation. This review will discuss the biological functions of the IL-17 signaling pathway, its dual-role in various diseases, as well as the challenges posed by current targeted therapies and future research directions.
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