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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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Stopping or continuing chronic antihypertensive therapy during hospitalization
Ziv Ribak1, Jacob David Miller2, Nitzan Burrack3
1Department of Internal Medicine F, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Journal of Internal Medicine
|April 3, 2026
Summary
Stopping blood pressure medication during hospital stays increases risks for acute kidney injury and death. Continuing antihypertensive therapy is safer for hospitalized patients, preventing adverse outcomes.
Area of Science:
- Cardiology
- Nephrology
- Hospital Medicine
Background:
- Elevated blood pressure is a frequent condition in hospitalized individuals.
- The impact of pausing chronic antihypertensive treatment during hospital stays is not well-understood.
Purpose of the Study:
- To determine the association between continuing versus stopping chronic antihypertensive medications during hospitalization and patient outcomes.
- To evaluate short-term and long-term adverse events linked to antihypertensive therapy management in hospitalized patients.
Main Methods:
- A retrospective propensity score-matched cohort study was conducted.
- Included were adult patients with chronic hypertension hospitalized between January 2014 and May 2024.
- Outcomes assessed included in-hospital and 90-day acute kidney injury (AKI), myocardial injury, stroke, and all-cause mortality.
Main Results:
- Discontinuation of antihypertensive therapy in internal medicine wards correlated with increased risks of in-hospital and 90-day AKI and mortality.
- In surgical departments, stopping medication was associated with higher in-hospital myocardial injury.
- These associations remained consistent across various subgroups, including those with infection-related admissions.
Conclusions:
- Withholding chronic antihypertensive therapy during hospitalization is linked to elevated risks of AKI and mortality.
- The findings indicate that discontinuing antihypertensive treatment during hospital stays offers no benefit and may potentially cause harm.
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