Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Radiomics-Driven Model to Distinguish Between Clinically Similar Myxopapillary Ependymomas and Lumbosacral Schwannomas.

Neurosurgery practice·2026
Same author

Health system learning enables generalist neuroimaging models.

Nature medicine·2026
Same author

Exploring the bioavailability and bioactivity of thiamine versus allithiamine: studies in <i>Drosophila melanogaster</i> and mice.

Frontiers in nutrition·2026
Same author

Identification of Auditory Brainstem Paddle Migration Arising from Fat Atrophy Utilizing MRI.

Journal of neurological surgery reports·2026
Same author

Spatial and multi-omic profiling reveals pericyte-derived CCL19 as a key prognostic factor in CNS lymphoma.

HemaSphere·2026
Same author

Subway-related trauma at an urban level I trauma center.

The American journal of emergency medicine·2026

Related Experiment Video

Updated: Apr 4, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

8.5K

Anatomic Predilection of Isocitrate Dehydrogenase-Mutant Gliomas: A Multi-Institutional Spatial Analysis.

Minjun Park1, Hannah Weiss1, Edward S Harake2

  • 1Department of Neurological Surgery, New York University Langone Medical Center, New York, New York, USA.

Neurosurgery
|April 3, 2026
PubMed
Summary

Adult diffuse gliomas show specific regional patterns. IDH-mutant tumors favor frontal lobes, while IDH-wildtype tumors show enrichment in the temporal lobe and insula, suggesting metabolic differences influence brain tumor formation.

Keywords:
AstrocytomaGliomagenesisIDH-mutantOligodendrogliomaSuperior frontal gyrus

More Related Videos

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
06:27

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

1.3K
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.4K

Related Experiment Videos

Last Updated: Apr 4, 2026

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

8.5K
A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
06:27

A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas

Published on: May 9, 2025

1.3K
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.4K

Area of Science:

  • Neuro-oncology
  • Cancer biology
  • Genomics

Background:

  • Tumorigenesis is driven by cancer cell and microenvironment interactions.
  • Regional brain microenvironment variability may influence glioma development.
  • Molecular subtypes of adult diffuse glioma have not been spatially mapped.

Purpose of the Study:

  • To quantitatively map the anatomic distribution of major adult diffuse glioma molecular subtypes.
  • To identify regional hotspots for IDH-mutant and IDH-wildtype gliomas.
  • To explore potential links between regional metabolism and glioma occurrence.

Main Methods:

  • Retrospective analysis of 204 IDH-mutant and 200 IDH-wildtype gliomas.
  • External cohort validation (190 IDH-mutant, 227 IDH-wildtype).
  • Microarray analysis of Allen Human Brain Atlas data to compare transcriptomic profiles.

Main Results:

  • IDH-mutant tumors showed 3.1-fold enrichment in superior/middle frontal gyri.
  • IDH-wildtype tumors exhibited 2.1-fold enrichment in the superior temporal gyrus.
  • Both IDH-mutant and wildtype tumors were significantly enriched in the insula; astrocytomas disproportionately occurred there compared to oligodendrogliomas.
  • Frontal lobe hotspots showed enrichment in cholesterol and fatty acid metabolism pathways.

Conclusions:

  • This study identifies distinct regional hotspots for IDH-mutant and IDH-wildtype gliomas.
  • Regional metabolic differences may contribute to the brain's variable susceptibility to gliomagenesis.
  • Findings provide a basis for investigating microenvironmental factors in glioma development.