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Updated: Apr 4, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Integrated Management of Malignant Arrhythmias in Pediatric LMNA-Related Cardiomyopathy Using Active-Fixation CRT-D

Yujia Wang1, Huafeng Wang1, Haiyan Xu1

  • 1Department of Cardiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.

JACC. Case Reports
|April 3, 2026
PubMed

Insights

This study presents a novel dual-track strategy for pediatric LMNA-related dilated cardiomyopathy (DCM). Combining cardiac resynchronization therapy with defibrillator (CRT-D) and epicardial ablation effectively manages life-threatening arrhythmias in young patients.

Area of Science:

  • Cardiology
  • Pediatric Electrophysiology
  • Genetic Cardiology

Background:

  • Pediatric LMNA-related dilated cardiomyopathy (DCM) presents a high risk of sudden cardiac death due to malignant arrhythmias.
  • Standard cardiac resynchronization therapy with defibrillator (CRT-D) implantation is challenging in children due to anatomical limitations affecting lead stability.
Abstract

Keywords:
cardiac resynchronization therapycardiomyopathygenetic disordersleft ventriclepediatric surgeryventricular tachycardia

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