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Updated: Apr 5, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
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Vertical Transmission of Type B Coxsackieviruses: A Systematic Review Emphasising Clinical Evidence and Seriousness

Aymen Halouani1, Hela Jaidane1

  • 1Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia.

Reviews in Medical Virology
|April 3, 2026
PubMed

Insights

Group B Coxsackieviruses (CV-B) can transmit from mother to infant, causing severe health issues like stillbirth and congenital malformations. This review details transmission, consequences, and prevention strategies for this underestimated route.

Area of Science:

  • Virology
  • Maternal-Fetal Medicine
  • Neonatology

Background:

  • Group B Coxsackieviruses (CV-B) are enteroviruses typically spread via the fecal-oral route.
  • Vertical transmission of CV-B from mother to infant is an underestimated but significant transmission route.
  • This transmission can occur via transplacental passage or during delivery through contaminated cervical swabs.

Purpose of the Study:

  • To elucidate the mechanisms of vertical transmission of CV-B.
  • To detail the diverse and serious consequences of vertical CV-B transmission.
  • To review associated diseases, preventive measures, and therapeutic strategies.

Main Methods:

  • Systematic review of clinical observations.
  • Analysis of existing literature on CV-B vertical transmission.

Main Results:

  • Vertical CV-B transmission is linked to adverse pregnancy outcomes including abortion and stillbirth.
  • Newborns affected by vertical CV-B transmission can experience severe morbidity and mortality.
  • Congenital malformations are a notable consequence in infants affected by vertical CV-B transmission.

Conclusions:

  • Vertical transmission of CV-B poses significant risks to both the fetus and the newborn.
  • Understanding transmission mechanisms is crucial for developing effective prevention and treatment strategies.
  • Further research and clinical vigilance are needed to mitigate the impact of vertical CV-B transmission.

Keywords:
abortion morbiditygroup B coxsackieviruses (CV‐B)placentavertical transmission

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