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Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF

Biao Ma1,2, Wenxin Lyu2, John Rizk2

  • 1Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Science Immunology
|April 3, 2026
PubMed
Summary

Two upstream open reading frames (uORFs) control TNF receptor 1 (TNFR1) levels, crucial for immune tolerance. This regulation prevents excessive inflammation and tissue damage, safeguarding against conditions like systemic inflammatory response syndrome.

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