Related Experiment Video
Updated: Apr 5, 2026
06:53
Scanning SQUID Study of Vortex Manipulation by Local Contact
Published on: February 1, 2017
7.4K
Precise capture of heterogeneous microscale targets using an integrated spherical vortex acoustic tweezer
Tao Zhang1, Yaqi Huang2, Zhuli Xu1
1School of Integrated Circuit, Huazhong University of Science and Technology, Wuhan 430074, China.
Ultrasonics
|April 3, 2026
Summary
This study introduces an integrated spherical vortex acoustic tweezer (ISVAT) for precise non-contact manipulation of biological cells. The acoustic micromanipulation device successfully controls and separates heterogeneous microparticles and mouse sperm cells.
Area of Science:
- Biophysics
- Acoustic Manipulation
- Microfluidics
Background:
- Acoustic micromanipulation offers non-contact cell handling for life sciences.
- Precise manipulation of morphologically diverse biological specimens is challenging.
Purpose of the Study:
- To develop an integrated spherical vortex acoustic tweezer (ISVAT) for advanced microscale manipulation.
- To demonstrate the device's capability in handling heterogeneous biological samples.
Main Methods:
- Utilized surface acoustic waves and a spiral interdigital transducer.
- Generated a Bessel-type spherical acoustic vortex for a 3D potential well.
- Operated the device at 40 MHz for microscopy compatibility.
Main Results:
- Achieved complex 2D trajectory control and selective separation of 20 μm polystyrene microspheres.
- Demonstrated a lateral trapping force of approximately 262 pN.
- Enabled stable capture and controlled rotation of heterogeneous mouse sperm cells.
Conclusions:
- The ISVAT is a high-performance acoustic platform for precise manipulation of diverse microscale targets.
- Offers a versatile tool for single-cell analysis and reproductive medicine research.
- Overcomes limitations in manipulating morphologically irregular biological specimens.
