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Updated: Apr 5, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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Redox-responsive drug delivery nanoparticles with integrated capabilities of ROS scavenging, lipid removal and

Lei Zhou1, Tao Chen1, Kebing Wang1

  • 1School of New Energy Engineering, Chengdu Technological University, Yibin, 644000, Sichuan, China.

Biomaterials Advances
|April 3, 2026
PubMed

Insights

This study introduces a novel nanoparticle system for atherosclerosis treatment. It targets plaques to reduce lipids and inflammation, offering a promising nanotherapy for cardiovascular disease.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cardiovascular Research

Background:

  • Atherosclerosis involves high reactive oxygen species (ROS), lipid buildup, and inflammation.
  • Nanotechnology offers targeted drug delivery for atherosclerosis, addressing its pathological features.

Purpose of the Study:

  • To develop a multifunctional nanotherapeutic system for atherosclerosis.
  • The system integrates ROS-responsive drug release, lipid removal, and anti-inflammatory actions.

Main Methods:

  • Engineered nanoparticles with a ROS-sensitive disulfide bond linking cyclodextrin and epigallocatechin gallate (EGCG).
  • Loaded nanoparticles with pitavastatin calcium (Pi) and utilized the enhanced permeability and retention (EPR) effect for targeted delivery.
  • Evaluated biosafety, ROS-scavenging, drug release, and effects on endothelial and smooth muscle cells, and inflammatory cytokines.

Main Results:

  • Nanoparticles showed excellent biosafety and ROS-scavenging ability.
  • Demonstrated intelligent, ROS-responsive drug release.
  • Promoted endothelial cell proliferation, inhibited smooth muscle cell hyperplasia, and reduced pro-inflammatory cytokines.
  • Showcased lipid-clearing capacity.

Conclusions:

  • The multifunctional nanotherapy effectively targets atherosclerotic lesions.
  • The system exhibits potential for treating atherosclerosis by addressing key pathological mechanisms.
Keywords:
Drug deliveryEpigallocatechin gallate (EGCG)Redox responseβ-cyclodextrin (β-CD)

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