Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

1.3K
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.3K
Types of RNA01:20

Types of RNA

16.3K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
16.3K
Types of RNA01:23

Types of RNA

73.9K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
73.9K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

19.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
19.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.9K
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The anti-viral protein Shiftless blocks p-body formation during KSHV infection.

The Journal of general virology·2026
Same author

Virally encoded interleukin-6 (vIL-6) coordinates with human IL-6 to modulate cytokine expression during KSHV infection.

bioRxiv : the preprint server for biology·2025
Same author

IL-6 Evades KSHV-Mediated Hyperadenylation repression via CRM1-Dependent Nuclear Export.

bioRxiv : the preprint server for biology·2025
Same author

A Balancing Act: The Viral-Host Battle over RNA Binding Proteins.

Viruses·2024
Same author

The antiviral protein Shiftless blocks p-body formation during KSHV infection.

bioRxiv : the preprint server for biology·2023
Same author

Viral manipulation of host cell gene expression.

Seminars in cell & developmental biology·2023

Related Experiment Video

Updated: Apr 5, 2026

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.9K

Hijacking by sequestration: An hCMV lncRNA reshapes the host transcriptome.

Mandy Muller1

  • 1Institute of Microbiology, University Hospital of Lausanne, University of Lausanne, 1011 Lausanne, Switzerland.

Molecular Cell
|April 3, 2026
PubMed
Summary
This summary is machine-generated.

Human cytomegalovirus (hCMV) uses a viral long noncoding RNA (lncRNA), RNA2.7, to control host gene expression and promote viral replication. This strategy involves sequestering proteins and stabilizing messenger RNAs (mRNAs).

More Related Videos

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

2.1K
MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

8.1K

Related Experiment Videos

Last Updated: Apr 5, 2026

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
14:40

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

3.9K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

2.1K
MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

8.1K

Area of Science:

  • Molecular Biology
  • Virology
  • Gene Expression Regulation

Background:

  • Human cytomegalovirus (hCMV) is a significant pathogen that establishes lifelong infections.
  • Viral long noncoding RNAs (lncRNAs) play crucial roles in modulating host cell functions during infection.
  • The lncRNA RNA2.7 is highly expressed during hCMV infection and its functions are not fully understood.

Purpose of the Study:

  • To investigate the mechanisms by which the viral lncRNA RNA2.7 influences host gene expression.
  • To understand how RNA2.7 contributes to optimizing the cellular environment for hCMV replication.

Main Methods:

  • The study likely involved molecular biology techniques to analyze RNA-protein interactions.
  • Methods may include mRNA stability assays and cell cycle analysis.
  • Investigating the impact of RNA2.7 on host protein binding and mRNA homeostasis.

Main Results:

  • RNA2.7 sequesters specific host RNA-binding proteins.
  • This sequestration leads to the stabilization of host messenger RNAs (mRNAs).
  • RNA2.7 enforces a G1 cell cycle arrest in host cells.

Conclusions:

  • The viral lncRNA RNA2.7 employs a sophisticated strategy to manipulate host gene expression.
  • By stabilizing host mRNAs and inducing cell cycle arrest, RNA2.7 creates a favorable cellular environment for hCMV replication.