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Published on: February 16, 2015
Turning drivers into regulators: In vivo CAR reprogramming of Tfh cells
Urmi Hofland1, Maria Montes De Oca Arena1, Laurence Morel1
1Department of Microbiology, Immunology & Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Abstract:
Autoimmune hepatitis (AIH) is a progressive, life-threatening liver disease that remains treated largely with broad immunosuppression. In this issue of Cell Stem Cell, Jing and colleagues reprogram follicular helper T (Tfh) cells in vivo into antigen-specific FOXP3⁺ CAR-Tfh cells to restore immune tolerance by rewiring core drivers of autoimmunity.
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