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Updated: Apr 5, 2026
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Isolation and characterization of Clostridioides difficile from wild animals from the Amazon biome
Hanna Gabriela da Silva Oliveira1, Raquel Leite Urbano1, Annanda Cordeiro Pereira1
1Laboratório de Medicina Veterinária Preventiva e Vacinologia, Instituto de Medicina Veterinária, Universidade Federal do Pará, Castanhal, 68740-970, PA, Brazil.
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Clostridioides difficile is an anaerobic pathogen associated with diarrhea in humans and animals. Despite its importance, the circulation of C. difficile in wildlife is still poorly understood. The present work investigated the presence of C. difficile in 179 samples from mammals, birds and reptiles from the Amazon biome. Eleven samples (6.1%) were positive for C. difficile. Four toxigenic isolates were identified in animals with varying degrees of human contact. Sequence types ST42, ST35, ST149 (from Clade 1), as well as a novel ST1241 (cryptic clade C-I), were identified. Notably, isolates ST42 and ST35 clustered closely with human clinical isolates.
