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Updated: Apr 5, 2026

Analyzing Mitochondrial Morphology Through Simulation Supervised Learning
Published on: March 3, 2023
Self-supervised multi-resolution learning for label-agnostic morphology representation and clustering of
Umapathi Krishnamoorthy1, Choon Kit Chan2, Chandrakant Sonawane3,4
1Department of Electronics and Communication Engineering, KIT- Kalaignarkarunanidhi Institute of Technology, Coimbatore, Tamil Nadu, India. umapathi.uit@gmail.com.
This study introduces a self-supervised learning framework for analyzing Scanning Electron Microscope images to detect semiconductor defects without needing labeled data. The method effectively clusters defect morphologies across different scales, improving industrial inspection capabilities.
Area of Science:
- Materials Science
- Computer Vision
- Semiconductor Manufacturing
Background:
- Scanning Electron Microscope (SEM) image analysis is crucial for semiconductor thin-film characterization, particularly for defect detection.
- Conventional methods often require labeled datasets or handcrafted features, limiting their adaptability in real-world industrial settings.
- This restricts the generalization capability of existing defect classification techniques.
Purpose of the Study:
- To propose a novel self-supervised multi-resolution learning framework for label-agnostic morphology representation learning and clustering of semiconductor thin-film defects.
- To enable unsupervised grouping of defect morphologies from SEM images without relying on prior defect labels.
- To evaluate the framework's efficacy using intrinsic clustering metrics and low-dimensional visualization techniques.
Main Methods:
- A self-supervised multi-resolution learning framework was developed using a dataset of 4591 industrial wafer inspection SEM images.
- The framework incorporates image pre-processing, a multi-resolution image pyramid for capturing morphologies at various scales, and a shared-weight convolutional encoder.
- The encoder is trained on an unlabeled dataset for unsupervised defect morphology grouping, with labels used only for post-hoc evaluation.
Main Results:
- The proposed self-supervised framework achieved a silhouette score of 0.50, outperforming traditional methods like GLCM (0.43), LBP (0.31), Wavelet features (0.45), and PCA (0.22).
- Normalized Mutual Information (NMI) values were moderate, reflecting the label-agnostic nature of the approach.
- UMAP and t-SNE visualizations confirmed coherent manifold structures and effective morphology-driven grouping, demonstrating scale-invariant clustering.
Conclusions:
- The proposed self-supervised multi-resolution learning framework offers a robust and label-agnostic approach for semiconductor defect clustering.
- The method effectively learns morphological representations and groups defects based on their characteristics across different spatial scales.
- This framework enhances the potential for automated and generalized defect detection in industrial semiconductor inspection.
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