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Published on: June 28, 2024
The role of protein Ser/Thr/Tyr kinases in bacteriophage infection
Lei Shi1, Carsten Jers2, Boyang Ji3
1Systems and Synthetic Biology Division, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden.
Abstract:
In the evolutionary arms race between bacteria and bacteriophages, both parties have evolved diverse defense systems and counter-defense strategies. Protein phosphorylation is a ubiquitous regulatory mechanism that enables rapid cellular responses to internal and external stimuli. Accordingly, protein phosphorylation-based responses have been established in both the bacterial host and the infecting phages. This review provides an overview of protein Ser/Thr/Tyr kinases involved in bacterial defense and phage counter-defenses, with a particular focus on insights gained from mass spectrometry-based phosphoproteomic analyses of phage infections.
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