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Related Experiment Video

Updated: Apr 5, 2026

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Dynamic brain network reconfiguration under stress: A multiphase fMRI study.

Xiao Luo1, Jiahao Huang1, Kun Shi1

  • 1Faculty of Psychology, Southwest University, Chongqing 400715, China; Key Laboratory of Cognition and Personality, Ministry of Education, Southwest University, Chongqing 400715, China.

Neuroimage
|April 4, 2026
PubMed
Summary
This summary is machine-generated.

Acute stress dynamically alters brain networks across three phases: pre-stress, stress, and post-stress. This study reveals rapid, reversible network changes and identifies sex differences in stress response and recovery.

Keywords:
AllostasisCortisolHidden markov modeling (HMM)ReconfigurationStress

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Area of Science:

  • Neuroscience
  • Psychophysiology
  • Computational Psychiatry

Background:

  • Acute stress triggers dynamic neural resource reallocation across distinct temporal phases.
  • Understanding brain network dynamics throughout the stress continuum (pre, during, post) is crucial but understudied.

Purpose of the Study:

  • To investigate whole-brain network dynamics continuously across all stress phases.
  • To characterize the spatiotemporal reconfiguration of brain networks during acute stress.
  • To identify individual differences in stress response and recovery.

Main Methods:

  • Employed Hidden Markov Modeling (HMM) to analyze continuous brain network dynamics.
  • Utilized two independent cohorts (ScanSTRESS and Montreal Imaging Stress Task).
  • Measured cortisol levels to correlate with neural changes.

Main Results:

  • Observed rapid and reversible spatiotemporal reconfigurations of large-scale brain networks.
  • Noted suppressed executive control network activation, enhanced sensory processing, and increased functional coupling during stress.
  • Found females exhibited higher state switching rates during stress; poorer recovery correlated with higher depression and anxiety scores.

Conclusions:

  • Proposed a Tri-Phase Network Reconfiguration Model for stress adaptation and allostasis.
  • Highlighted phase-specific brain state repertoires and directed transitions.
  • Provided a dynamic framework for understanding stress adaptation and psychopathology.