Patient-specific liver assembloids for disease modeling
Pingxin Sun1, Chao Wang1, Wenlin Li2
1Department of Cell Biology, Naval Medical University, Shanghai 200433, China.
Trends in Molecular Medicine
|April 4, 2026
Abstract:
Yuan et al. present a novel method for expanding adult human hepatocytes and assembling them with cholangiocytes and portal fibroblasts into patient-specific periportal liver assembloids. This system recapitulates liver architecture and function, enabling personalized disease modeling, including liver fibrosis, and offering new possibilities for precision hepatology and regenerative medicine.
