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Lymphocyte Antigen 6G Mediates Vagotomy-Associated Reduction in Body Weight
Ting Liu1,2, April S Caravaca1,2, Min Cai2
1Laboratory of Immunobiology, Center for Bioelectronic Medicine, Division of Cardiovascular Medicine, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Summary
Vagal nerve signaling influences body weight and adipose tissue mass. Disrupting this signaling increases neutrophil infiltration, which mediates weight loss and regulates energy balance in white adipose tissue.
Area of Science:
- Neuroscience
- Metabolic Physiology
- Immunology
Background:
- Adipocyte function is crucial for metabolic and cardiovascular health.
- Interorgan neuroimmune crosstalk is vital for adipose tissue function, but mechanisms are unclear.
- The vagus nerve impacts physiological functions like inflammation and weight control.
Purpose of the Study:
- To investigate the role of vagal signaling in maintaining epididymal white adipose tissue (eWAT) homeostasis.
- To determine how disrupting vagus nerve signaling affects adipose tissue physiology.
Main Methods:
- Vagotomy in male animals to disrupt vagal signaling.
- Assessment of body weight and eWAT mass.
- Analysis of Ly6G+ cell infiltration in eWAT.
- Utilizing neutrophil-deficient mice (Ly6GcreMcl1fl/fl) and anti-Ly6G antibody treatment.
Main Results:
- Vagotomized animals exhibited reduced body weight and eWAT mass compared to controls.
- Increased infiltration of Ly6G+ cells was observed in the eWAT of vagotomized animals.
- Neutrophil deficiency or depletion significantly attenuated vagotomy-associated weight loss.
Conclusions:
- Vagal signaling plays a role in regulating body weight and eWAT homeostasis.
- Ly6G+ cells mediate the vagotomy-associated reduction in weight.
- These findings highlight the involvement of Ly6G+ cells in eWAT energy regulation.
