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Comparison of AI-generated radiology impressions: a multi-stakeholder evaluation
Sharang Phadke1, Nivedita Suresh1, Zachary Allen1
1Rad AI, San Francisco, CA, USA.
NPJ Digital Medicine
|April 4, 2026
Summary
A custom AI model generated oncologic computed tomography (CT) impressions comparable to human radiologists, while general AI models were less preferred. Clinicians found AI-generated impressions safe and useful.
Area of Science:
- Medical Imaging Analysis
- Artificial Intelligence in Healthcare
- Radiology Reporting
Background:
- Artificial intelligence (AI) is increasingly used in medical imaging.
- Evaluating the performance of AI-generated radiology reports is crucial for clinical adoption.
- Domain-specific AI models may offer advantages over general-purpose models.
Purpose of the Study:
- To compare the quality of AI-generated impressions from a custom domain-specific AI model and a general large language model (LLM) against original radiologist-authored impressions.
- To assess clinician preferences and perceptions of completeness, correctness, conciseness, clarity, clinical utility, and patient harm for different impression types.
Main Methods:
- Retrospective, blinded evaluation of 200 oncologic computed tomography (CT) reports.
- Comparison of original radiologist impressions, custom AI model impressions, and general LLM impressions.
- Rating of impressions by 10 clinicians (radiologists and oncologists) on key quality metrics.
Main Results:
- Radiologists preferred original and custom AI impressions over general LLM impressions.
- Oncologists showed no significant preference among impression types.
- Custom AI impressions demonstrated near parity with human-generated impressions in quality.
- General LLM impressions were longer and less concise but slightly more complete.
- Patient harm ratings were uniformly low across all impression types.
Conclusions:
- Domain-specific AI models show promise in generating high-quality radiology impressions.
- AI-generated impressions are perceived as safe and clinically useful by clinicians.
- Further research may optimize general LLMs for radiology reporting to improve conciseness and preference.
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