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Decoding the SHOX2 methylation-expression paradox in lung adenocarcinoma: Dual-regulatory methylation patterns drive

Yang Zhou1, Ruochuan Zang1, Zhao Li2

  • 1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Cancer Letters
|April 5, 2026
PubMed

Keywords:
DNA methylationEpigenetic diagnosticsGene body methylationLung adenocarcinoma (LUAD)SHOX2

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