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In-vitro Mutagenesis

In-vitro Mutagenesis

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Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

Deciphering ferroptosis in gene-edited mouse models.

Yingying Yu¹, Yizhou Lu¹, Xuexian Fang²

¹Department of Nutrition and Toxicology, School of Public Health and Nursing, Hangzhou Normal University, Hangzhou, China.

Trends in Molecular Medicine

|April 5, 2026

Summary

This summary is machine-generated.

Ferroptosis, a cell death process, is vital in disease. This review synthesizes mouse model studies to clarify ferroptosis

Keywords:

animal models diseases ferroptosis knockout overexpression

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Area of Science:

Biomedical Science
Cell Biology
Pathophysiology

Background:

Ferroptosis, an iron-dependent regulated cell death, is crucial in disease.
Mice are key models for studying ferroptosis and disease links.
A comprehensive review of ferroptosis research using mouse models is needed.

Purpose of the Study:

To review ferroptosis molecular pathways and regulatory genes.
To integrate evidence from gene-edited mouse models.
To explore ferroptosis' pathophysiological relevance and clinical translation.

Main Methods:

Literature review of ferroptosis mechanisms.
Analysis of gene-edited mouse models.
Synthesis of phenotypic and mechanistic insights.

Main Results:

Detailed outline of ferroptosis pathways: iron metabolism, lipid peroxidation, and defense systems.
Highlighting key regulatory genes in ferroptosis.
Integration of functional data from mouse models demonstrating ferroptosis' role in diseases.

Conclusions:

Ferroptosis is a significant factor in disease pathogenesis and treatment.
Gene-edited mouse models offer valuable insights into ferroptosis.
Further research can accelerate clinical applications of ferroptosis targeting.