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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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Biogenic Silver Nanoparticles: Revolutionizing Diabetic Wound Therapy.

Mohammad Sameer Khan1, Shaheen Shabbir2, S M Kawish1

  • 1Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, 110062, India.

Pharmaceutical Nanotechnology
|April 5, 2026
PubMed
Summary
This summary is machine-generated.

Biogenic silver nanoparticles (AgNPs) show promise for treating diabetic wounds by reducing amputation risk. This review explores their efficacy in wound dressings, potential toxicities, and future clinical applications.

Keywords:
Silver formulationclinical prospectsdiabetic woundnanotechnologysilver nanoparticles.wound dressings

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Diabetic Wound Management

Background:

  • Diabetic wounds are a severe complication, often leading to amputation due to ineffective conventional therapies.
  • Advanced materials, especially nanoscaffolds and nanofibers, are crucial for improving diabetic wound healing.
  • Silver nanoparticles (AgNPs) offer antibacterial and anti-inflammatory benefits for chronic wound repair.

Purpose of the Study:

  • To review the role and mechanisms of biogenic silver nanoparticles (AgNPs) in managing diabetic wounds.
  • To evaluate the efficacy of AgNPs in wound dressings and marketed formulations.
  • To discuss AgNP toxicity, clinical trials, and future prospects in wound healing.

Main Methods:

  • Literature review focusing on biogenic silver nanoparticles (AgNPs) for diabetic wound management.
  • Analysis of AgNP mechanisms, efficacy in wound dressings, and marketed products.
  • Examination of toxicity data, clinical trial outcomes, and future research directions.

Main Results:

  • Biogenic AgNPs demonstrate potent antibacterial and anti-inflammatory properties beneficial for diabetic wound healing.
  • Nanofiber and nanoscaffold applications of AgNPs show promise in enhancing cellular and molecular interactions for tissue repair.
  • Marketed AgNP formulations exist, but potential toxicities require careful consideration.

Conclusions:

  • Biogenic AgNPs hold significant potential for improving diabetic wound management, particularly when incorporated into wound dressings.
  • Further research and clinical trials are necessary to fully understand and mitigate potential AgNP toxicities.
  • AgNPs represent a promising avenue for innovative treatments in chronic wound care, reducing amputation rates.