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Optimizing Physical Exercise for Chronic Pain Relief in Hemophilia Patients.
Xiaolian Wu1, Jing Ni1, Baodong Ye1
1Hematology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310003, China.
Summary
Physical exercise (PE) effectively manages chronic pain in adults with hemophilia, improving function and well-being. Adherence to PE programs offers significant benefits and a favorable safety profile for hemophilia patients.
Area of Science:
- Medical Science
- Rehabilitation Medicine
- Hematology
Background:
- Chronic pain is a significant challenge for adults with hemophilia.
- Management strategies often require a multidisciplinary approach.
Purpose of the Study:
- To evaluate the efficacy and safety of physical exercise (PE) for chronic pain in adults with hemophilia.
- To synthesize evidence for best-practice recommendations.
Main Methods:
- Systematic review of literature from December 2014 to August 2025.
- Inclusion of clinical decision documents, guidelines, systematic reviews, and consensus statements.
- Thematic synthesis of evidence and quality appraisal using JBI tools.
Main Results:
- Sixteen publications yielded 33 best-evidence statements across six domains.
- Physical exercise demonstrated significant pain reduction and improved physical function.
- PE showed a favorable safety profile when combined with prophylactic treatment.
Conclusions:
- Implementing and adhering to PE interventions offers substantial benefits for chronic pain management in adults with hemophilia.
- This evidence supports the design of individualized, multimodal exercise programs.
- Collaborative and tailored interventions are crucial for optimal outcomes.
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