Modification of Mechanical and Functional Properties of Titania Nanotubes Using [Pt₂(6NNqui)Cl₄] Complex Bonded...

Titanium alloys are basic materials used in implantology. Their properties can be modified in many ways, e.g., by morphological changes or covering with different bioactive molecules. Platinum(II) complexes are a significant group of anticancer drugs. In an organism, they undergo many chemical processes. A ligand substitution with the S-donor ligands (glutathione (GSH), metallothioneins) is among the most important. This process can be applied to the modification of titanium alloys (Ti6Al4V) with platinum(II) complexes, e.g., [Pt₂(6NNqui)Cl₄] (PtQ6). The paper presents a modification of the Ti6Al4V alloy with titania nanotubes and the studied complex, using the bridging ligand (3-mercaptopropyl)triethoxysilane (MPTES). Moreover, a kinetic study on chloride substitution in the studied bimetallic cisplatin analogue (PtQ6) by L-cysteine, an amino acid that is a part of GSH and metallothioneins, is also presented. It is a good way to get locally active implants in the targeted anticancer therapy. The produced material is characterized with spectral and microscopic methods, including XPS (X-ray photoelectron spectroscopy). The mechanism of the substrate modification with platinum(II) complex is based on the substitution process. The nanomechanical properties of the modified and functionalized substrate are also tested in the indentation tests.