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Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
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Bispecific Mini-Antibody with an Anti-CD14 Module Effectively Controls Bioavailability of the Human Tumor Necrosis
Ivan Y Konev1, Kirill V Korneev2, Stanislav V Kozlovsky3
1Division of Immunobiology and Biomedicine, Sirius University of Science and Technology, Sochi, Krasnodar Region, 354349, Russia.
None:
Systemic blockade of proinflammatory cytokines such as IL-1, TNF, and IL-6 using therapeutic antibodies has proven effective in treating a wide range of autoimmune and other chronic inflammatory diseases. However, such blockade also suppresses non-redundant protective and homeostatic functions of cytokines, leading to a number of undesirable side effects. In this study, a novel bispecific mini-antibody featuring modules targeting human TNF and CD14 demonstrated efficacy in controlling TNF secretion from human peripheral blood monocytes. Administration of this antibody protected humanized TNF mice from lethal hepatotoxicity induced by a combination of LPS and D-galactosamine.
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