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Updated: Apr 7, 2026

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
Long-Term Outcomes of Patients Seeking Specialized Health Care for Persisting Postconcussion Symptoms After a Mild
Linda Fordal1, Jonas Stenberg2, Turid Follestad3
1Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway; Clinic of Rehabilitation, St. Olav's University Hospital, Trondheim University Hospital, Trondheim, Norway.
Objective:
To examine long-term outcomes of persisting postconcussion symptoms (PPCS) after mild head injury in patients seeking specialist care.
Design:
Longitudinal cohort study. Baseline interview at outpatient admission and follow-up interviews at 3, 6, 12, 18, 24, 30, 36, 48, and 60 months postinjury, and 5 years after outpatient admission.
Setting:
Rehabilitation clinic.
Participants:
Patients (N=191) with PPCS after mild head injury over the past 5 years.
Interventions:
Not applicable.
Main Outcome Measures:
Symptoms assessed by Rivermead Postconcussion Symptoms Questionnaire, functioning via Glasgow Outcome Scale-Extended and return to full-time work. Linear and logistic mixed models with and without interaction terms evaluated outcomes over time, while within-subject change was assessed from participants' first to last assessments.
Results:
The sample comprised 800 assessments (mean 4.2 [SD, 1.7] per participant). Patients were divided into groups by time from injury to outpatient admission (group 1: 0-3mo [n=44]; group 2: 3-6mo [n=54]; group 3: 6-12mo [n=47]; group 4: 12-24mo [n=26]; group 5: 24-60mo [n=20]). Although the groups had similar clinical characteristics at outpatient admission, their outcomes over time differed. Substantial symptom reduction and functional improvement were observed over time in groups 1-4, but not in group 5. Most symptom relief across groups occurred in the months after outpatient admission.
Conclusions:
In patients seeking care for PPCS, most exhibited improvement over time and worsening was rare. However, many still experienced symptoms years after outpatient admission, and outpatient admission ≥2 years postinjury was associated with significantly poorer outcomes.
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