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School Difficulties and Long COVID in Children and Adolescents
Harrison T Reeder1, Lawrence C Kleinman2, Melissa S Stockwell3
1Massachusetts General Hospital Biostatistics (HT Reeder, T Thaweethai, DB Pant, A Krishnamoorthy, and AS Foulkes), Somerville, Mass; Department of Medicine (HT Reeder, T Thaweethai, and AS Foulkes), Harvard Medical School, Boston, Mass.
Insights
Pediatric Long COVID negatively impacts school performance and social interactions in children and adolescents. This highlights the urgent need for tailored school support services for affected youth.
Area of Science:
- Pediatric Health
- Infectious Diseases
- Public Health
Background:
- Pediatric Long COVID (LC) is a chronic condition following SARS-CoV-2 infection in children and adolescents.
- While clinical symptoms are increasingly studied, the functional impacts of pediatric LC, particularly in school settings, remain under-described.
Purpose of the Study:
- To assess the association between pediatric Long COVID and school-related functional outcomes in school-aged children and adolescents.
- To investigate impacts on academic performance, attention, peer relationships, and the need for Individualized Education Programs (IEPs).
Main Methods:
- Analysis of cross-sectional data from the NIH-funded Researching COVID to Enhance Recovery (RECOVER) pediatric cohort.
- Inclusion of school-age children (6-11 years) and adolescents (12-17 years) with and without LC.
- Matched analyses to estimate risk ratios for outcomes including worsened grades, attention difficulties, limited peer interaction, and IEP status.
Main Results:
- Children and adolescents with LC showed significantly higher rates of worsened grades compared to peers without LC (adjusted RR 2.18 for school-age, 2.39 for adolescents).
- Pediatric LC was associated with increased difficulty paying attention, reduced social engagement with friends, and a greater likelihood of requiring an IEP in both age groups.
Conclusions:
- Long COVID in children and adolescents is demonstrably linked to negative school-related functional outcomes.
- The findings underscore a critical need for developing and implementing effective school-based services to support students affected by pediatric LC.
Objective:
Pediatric Long COVID (LC) is an infection-associated chronic condition following SARS-CoV-2 infection. While research has begun to elucidate clinical phenotypes, functional impacts are not well described.
Methods:
Cross-sectional data from the NIH-funded Researching COVID to Enhance Recovery (RECOVER) pediatric observational cohort were analyzed to assess associations in school-age children (6 to 11 years) and adolescents (12 to 17 years) between LC and caregiver-reported school-related functional outcomes. LC was defined using RECOVER age group-specific symptom-based LC research indices. The primary outcome was worsening of child grades. Secondary outcomes included difficulty paying attention, limited fun with friends, and having an Individualized Education Program (IEP). Using age-stratified analyses, children with and without LC were matched based on age, sex, and dates of infection and enrollment, to estimate risk ratios (RRs) between LC and each outcome.
Results:
The cohort included 1976 children (406 school-age, 1570 adolescent). About 18% of school-age children and 29% of adolescents with LC had reported worsened grades, compared to 7% and 11% without LC, respectively [school-age: adjusted RR 2.18 (95% CI: 1.15-4.11); adolescent: adjusted RR 2.39 (95% CI: 1.86-3.06)]. In both age groups, children with LC were more likely to have difficulty paying attention, limited fun with friends, and IEPs.
Conclusions:
LC in school-age children and adolescents was negatively associated with functional school-related outcomes, including academic performance, attention, and peer interactions. As LC affects a substantial proportion of U.S. children, these findings highlight the urgent need to develop, provide, and evaluate school-related services for children and adolescents with LC.
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