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Labdane diterpenoids from the Chinese liverwort Pallavicinia ambigua and their cytotoxic effect
Chun-Yang Zhang1, Zhao-Jun Chu2, Shuang-Zhi Yuan2
1Department of Natural Products Chemistry, Key Laboratory of Chemical Biology of the Ministry of Education, Shandong University, Jinan, 250012, People's Republic of China; Department of Pharmacy, The Fourth Affiliated Hospital of Soochow University, No. 9, Chongwen Road, Suzhou, 215123, People's Republic of China.
Abstract:
Seven previously undescribed highly oxidized labdane lactones [pallamoids A-G (1-7)], featuring five 6/6/5/5 and two 6/6/5 cyclic systems, and six known compounds (8-13) were isolated from the Chinese liverwort Pallavicinia ambigua. Their structures were determined by high-resolution mass spectrometry, nuclear magnetic resonance, and single-crystal X-ray diffraction analysis. Biologically, compounds 1-5 and 8 showed selective inhibitory activity against the human prostate cancer (PC-3) cell line with half-maximal inhibitory concentration (IC50) values of 5.7-10.1 μM via an apoptotic pathway.
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