Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative urge urinary incontinence and outcomes after thulium laser enucleation for benign prostatic hyperplasia.

World journal of urology·2026
Same author

Interactomics-driven discovery of alkaloid biosynthetic pathways in kratom.

bioRxiv : the preprint server for biology·2026
Same author

Genetic basis for repeated evolution of compound leaves over deep time.

The Plant journal : for cell and molecular biology·2026
Same author

Antibody-conjugated SIS3-loaded PLGA@polydopamine nanoparticles alleviate cardiac fibrosis by modulating Smad3 signaling in myofibroblasts.

Journal of nanobiotechnology·2026
Same author

Mineralization of Bouligand-structured collagen matrices derived from fish scales with enhanced mechanical properties and biocompatibility.

Journal of materials chemistry. B·2026
Same author

RNF130 inhibits the proliferation, migration and invasion of osteosarcoma through DAB1 mediated suppression of the PI3K/AKT signaling pathway.

Cellular signalling·2026

Related Experiment Video

Updated: Apr 7, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.2K

Oriented Nano-Homogeneous Biomimetic Scaffolds Regulate Cell Alignment and Promote Endogenous Bone Regeneration.

Hui Yu1,2, Wutong Zhou1, Yage Hou1

  • 1Marine College, Shandong University, Weihai, China.

Small (Weinheim an Der Bergstrasse, Germany)
|April 5, 2026
PubMed
Summary

This study developed an oriented bone scaffold using tunicate nanocellulose, carbon nanotubes, and chitosan for enhanced bone regeneration. The biomimetic scaffold demonstrated superior osteogenic performance and antibacterial properties.

Keywords:
anisotropy structurebiomimetic scaffoldsbone repaircarbon nanotubetunicate nanocellulose

More Related Videos

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.5K
Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

4.5K

Related Experiment Videos

Last Updated: Apr 7, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.2K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

2.5K
Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
07:14

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

4.5K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background:

  • Conventional bone grafts face limitations in osteoinductivity and osteoconductivity due to poorly defined structures.
  • Native bone's anisotropic architecture offers a model for improved scaffold design.
  • Developing advanced biomaterials is crucial for effective endogenous bone regeneration.

Purpose of the Study:

  • To create a nano-homogeneous, radially oriented hybrid scaffold for enhanced endogenous bone regeneration.
  • To investigate the role of tunicate nanocellulose (TCNC), carbon nanotubes (CNT), and chitosan (CS) in scaffold fabrication.
  • To evaluate the osteogenic and antibacterial properties of the developed scaffold.

Main Methods:

  • Directional freeze-casting technology was used to construct radially oriented scaffolds.
  • Tunicate nanocellulose (TCNC) was employed as a dispersant and reinforcer for carbon nanotubes (CNT) in a chitosan (CS) matrix.
  • In situ biomimetic mineralization was performed to incorporate hydroxyapatite (HAP), and photothermal properties were assessed.

Main Results:

  • The oriented scaffold exhibited a nano-homogeneous structure with uniformly distributed hydroxyapatite (HAP).
  • Carbon nanotubes (CNT) provided strong photothermal antibacterial capability (>98% against S. aureus).
  • The anisotropic channels significantly promoted cell adhesion, alignment, proliferation, and superior osteogenic performance in a rat cranial defect model, reaching 0.688 g/cm³ bone mineral density.

Conclusions:

  • A structurally and functionally integrated biomimetic strategy was demonstrated for enhancing endogenous bone regeneration.
  • Nano-homogeneous, anisotropic architectures are critical for guiding effective tissue repair.
  • The developed oriented scaffold shows significant potential for bone tissue engineering applications.