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Updated: Jul 3, 2026
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
Clinical features and maternal-fetal outcome of pregnancy with aplastic anaemia: A single-centre retrospective study
Xiaoxia Wu1,2, Zhen Yang1,2, Xinhui Zhang1,2
1National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, Jiangsu Key Laboratory of Hematologic Diseases, The First Affiliated Hospital of Soochow University, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China.
Pregnancy complicated by aplastic anaemia (AA) is rare but high risk, with historically poor maternal-fetal outcomes. Contemporary multidisciplinary management may improve prognosis, underscoring the need to clarify current outcomes and risk factors. We conducted a single-centre retrospective cohort study of 54 women with AA who had a total of 65 pregnancies, including those diagnosed with AA during pregnancy (n = 8) and those with a pre-existing AA diagnosis (n = 57). Most patients with new-onset AA presented with severe cytopenia at diagnosis. Although none responded to therapy during pregnancy, all six who continued their pregnancies had live births; two opted out due to severe cytopenia. In the pre-existing AA group, 88% of pregnancies resulted in live births, with a 47% rate of severe maternal or fetal complications. Pre-delivery haemoglobin and platelet counts were significantly lower in the complication group (73 g/L and 20 × 109/L vs. 85 g/L and 29 × 109/L, p < 0.05). Active disease (relapse or lack of remission) before delivery was strongly associated with adverse outcomes (78% vs. 37%, p = 0.002). No maternal deaths or neonatal haematological abnormalities were observed. Pregnancy with AA can achieve favourable outcomes with multidisciplinary management. Pre-delivery disease activity and haematological parameters (haemoglobin and platelet counts) are significant predictors of complications.
Pregnancy complicated by aplastic anaemia (AA) is rare but high risk, with historically poor maternal-fetal outcomes. Contemporary multidisciplinary management may improve prognosis, underscoring the need to clarify current outcomes and risk factors. We conducted a single-centre retrospective cohort study of 54 women with AA who had a total of 65 pregnancies, including those diagnosed with AA during pregnancy (n = 8) and those with a pre-existing AA diagnosis (n = 57). Most patients with new-onset AA presented with severe cytopenia at diagnosis. Although none responded to therapy during pregnancy, all six who continued their pregnancies had live births; two opted out due to severe cytopenia. In the pre-existing AA group, 88% of pregnancies resulted in live births, with a 47% rate of severe maternal or fetal complications. Pre-delivery haemoglobin and platelet counts were significantly lower in the complication group (73 g/L and 20 × 109/L vs. 85 g/L and 29 × 109/L, p < 0.05). Active disease (relapse or lack of remission) before delivery was strongly associated with adverse outcomes (78% vs. 37%, p = 0.002). No maternal deaths or neonatal haematological abnormalities were observed. Pregnancy with AA can achieve favourable outcomes with multidisciplinary management. Pre-delivery disease activity and haematological parameters (haemoglobin and platelet counts) are significant predictors of complications.
