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Mortality From Amyotrophic Lateral Sclerosis in Finland 1987-2022.

Milla Laine1, Jani Raitanen2,3, Anssi Auvinen2

  • 1Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.

European Journal of Neurology
|April 6, 2026
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Summary

Amyotrophic lateral sclerosis (ALS) mortality has nearly doubled in Finland over 35 years. This fatal neurodegenerative disease shows a concerning upward trend, particularly in older age groups and women.

Keywords:
Finlandamyotrophic lateral sclerosisepidemiologymortalitymotor neuron disease

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Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease.
  • Understanding mortality trends is crucial for public health planning and research.

Purpose of the Study:

  • To assess changes in Amyotrophic lateral sclerosis (ALS) mortality in Finland.
  • To analyze trends from 1987 to 2022.

Main Methods:

  • Utilized national death statistics (ICD-10 code G12.2) and population data.
  • Calculated crude and age-standardized mortality rates.
  • Employed Poisson and joinpoint regression to analyze trends and identify significant changes.

Main Results:

  • Age-standardized ALS mortality increased from 2.24/100,000 in 1987 to 4.21/100,000 in 2022.
  • Overall annual increase of 1.7%, with higher rates in women (2.0%) and the oldest age group (2.4%).
  • A significant trend change in women was observed between 1987-1997.

Conclusions:

  • ALS mortality has nearly doubled in Finland over 35 years, mirroring trends in other nations.
  • The findings highlight the need for further investigation into the underlying causes of increased ALS mortality.