Catalytic Asymmetric Construction of Chiral Indoloazepine-Based Spirooxindoles via Formal [6+1] Cycloadditions
Qiong Wu1, Shuang Yang1, Tianzi Huang1
1School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou 221018, China.
Abstract:
The first chiral phosphoric acid-catalyzed formal [6+1] cycloaddition of (2-aminobenzyl)indoles with isatins has been developed, efficiently affording biologically important chiral indoloazepine-based spirooxindoles in high yields (up to 99%) and excellent enantioselectivities (up to 97:3 er). Notably, this novel class of chiral indoloazepine-based spirooxindoles exhibits potent cytotoxicity against human liver cancer cell line HepG2.
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