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Updated: Apr 7, 2026
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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
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Meta-Analysis of Genetic Variants Associated With HBV Infection Susceptibility and Hepatocellular Carcinoma Risk.
So Yoon Lee1, Hyoung Doo Shin1,2
1Department of Life Science, Sogang University, Seoul, Republic of Korea.
Journal of Viral Hepatitis
|April 6, 2026
Summary
Genetic variations influence Hepatitis B virus (HBV) infection and liver cancer (HCC) risk. This meta-analysis identifies key genetic factors, including immune and metabolic genes, contributing to HBV persistence and HCC development in East Asian populations.
Area of Science:
- Genetics
- Hepatology
- Immunology
Background:
- Hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) pose significant global health challenges.
- Genetic variations are increasingly recognized as crucial factors in disease susceptibility and progression.
- Previous genetic association studies have yielded inconsistent results, limiting clinical application.
Purpose of the Study:
- To conduct a comprehensive meta-analysis of genetic variations associated with HBV infection and HCC risk.
- To investigate genetic factors across diverse etiologic pathways, including viral, alcohol-related, and metabolic liver diseases.
- To clarify the role of genetic variations in HBV persistence and HCC development.
Main Methods:
- Performed a meta-analysis of East Asian cohorts.
- Analyzed eight single nucleotide polymorphisms (SNPs) for HBV infection susceptibility.
- Analyzed 11 SNPs for HCC risk across multiple etiologic subgroups.
Main Results:
- CD40 rs1883832 and C2 rs9267665 showed strong, consistent associations with HBV infection susceptibility.
- HLA-DPA1 rs3077 and HLA-DQB1 rs2856718 were associated with HBV infection susceptibility, with heterogeneity.
- Identified distinct genetic risk variants for HCC linked to specific causes (HBV, HCV, alcohol, NAFLD).
Conclusions:
- Immune-related genes and HLA class II variants are implicated in HBV persistence.
- Metabolic gene variants are significant contributors to HCC risk.
- This meta-analysis provides a clearer understanding of genetic influences on HBV infection and HCC across different etiologies.
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