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Updated: Apr 7, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Spirocyclization-Enabled Remote Phosphorothiolation of Nonactivated Arenes via Dual Photoredox/Copper-Catalyzed
Jiale Zhang1,2,3, Siqing Liu2, Denghui Ma4
1College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
None:
Spirocyclic frameworks are key structural motifs in bioactive molecules, driving ongoing efforts to develop efficient and sustainable synthetic methods. Herein, we report a synergistic photocatalysis/copper dual-catalytic system that enables direct dearomative spirocyclization via the simultaneous incorporation of phosphorothioate groups in a single synthetic operation. This strategy allows rapid, selective construction of complex spirocenters from simple nonactivated aromatic precursors, exhibits broad substrate scope, including bioactive relevant scaffolds, and provides a robust platform for diversity-oriented synthesis with significant potential in drug discovery.
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