Related Experiment Video

Updated: Apr 7, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
10:11

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Published on: September 27, 2014

37.2K

The Mengla virus (Filoviridae: Dianlovirus)

T E Sizikova1, V N Lebedev1, S V Borisevich1

  • 148 Central Scientific Research Institute of the Ministry of Defens of the Russian Federation.

Voprosy Virusologii
|April 6, 2026
PubMed
Abstract

Insights

New filoviruses found in Asian bats, including Mengla virus, show genetic diversity and potential for human transmission. Further research is needed to understand their pathogenic potential and public health implications.

Area of Science:

  • Virology
  • Bat-borne viruses
  • Emerging infectious diseases

Background:

  • Filoviruses, including Ebola and Marburg viruses, are associated with pteropodid bats and cause hemorrhagic fevers.
  • Recent discoveries of novel filoviruses in South and Southeast Asian bats necessitate investigation into their genetic diversity and pathogenicity.

Purpose of the Study:

  • To investigate the genetic diversity and pathogenic potential of newly discovered filoviruses associated with bats in South and Southeast Asia.
  • To review existing literature data on filovirus discovery, characterization, and biological properties.

Main Methods:

  • Literature review of published studies on filovirus detection and molecular characterization in pteropodid bats.
  • Analysis of data on virus discovery, genome organization, taxonomy, and experimental assessment of biological properties.

Main Results:

  • Several novel filoviruses were identified in pteropodid bats from South and Southeast Asia using metagenomic sequencing.
  • Mengla virus, detected in China, represents a new genus, Dianlovirus, within the Filoviridae family due to significant genetic divergence.
  • Experimental studies suggest Mengla virus may infect various vertebrate hosts, including humans.

Conclusions:

  • Filoviridae family members are geographically widespread in South and Southeast Asia, carried by pteropodid bats.
  • The potential for cross-species transmission of newly discovered filoviruses, like Mengla virus, poses a risk for novel infections in endemic regions.
  • While human disease from these novel viruses is undocumented, continued surveillance is crucial.
Keywords:
Mengla virusbatsfilovirusesnatural reservoir of filovirusessequence of genomesequencing of nucleic acids

More Related Videos

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment08:34

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

10.2K
Single Cell Micro-aspiration as an Alternative Strategy to Fluorescence-activated Cell Sorting for Giant Virus Mixture Separation09:50

Single Cell Micro-aspiration as an Alternative Strategy to Fluorescence-activated Cell Sorting for Giant Virus Mixture Separation

Published on: October 27, 2019

7.6K

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.4K
Viruses of Archaea01:29

Viruses of Archaea

Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
657
Introduction to Virus01:28

Introduction to Virus

Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
2.7K
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.7K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
1.1K
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
44