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Updated: Apr 7, 2026

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Adjunctive Serum Drops to Paper Patch for Tympanic Membrane Perforation.

Yalda Yazdani1, Ella J Lee1, Karen Tawk1

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Autologous serum drops significantly improve tympanic membrane (TM) perforation closure when combined with paper patch myringoplasty. This safe, cost-effective treatment offers a new option for chronic perforations unresponsive to initial patching.

Keywords:
myringoplastypaper patchperforationserum dropstympanic membrane

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Area of Science:

  • Otolaryngology
  • Regenerative Medicine

Background:

  • Chronic tympanic membrane (TM) perforations often fail to heal with standard treatments.
  • Paper patch myringoplasty is a common initial approach, but success rates can be limited in persistent cases.

Purpose of the Study:

  • To assess the efficacy of autologous serum drops combined with secondary paper patch myringoplasty for TM perforation closure.
  • To evaluate this combined approach in patients with a history of failed primary patching.

Main Methods:

  • Retrospective chart review of 81 patients with chronic TM perforations.
  • Comparison of an experimental group (serum drops + paper patch) versus a control group (paper patch alone).
  • Kaplan-Meier analysis and Cox regression to determine time-to-closure and influencing factors.

Main Results:

  • Significantly higher closure rates in the experimental group (54.5%) vs. control (21.6%; P=.002).
  • Autologous serum drops enhanced healing outcomes, even in previously unresponsive perforations.
  • Smaller and posterior perforations demonstrated better closure rates; no adverse effects reported.

Conclusions:

  • Autologous serum drops combined with paper patch myringoplasty represent a safe and effective non-surgical option for chronic TM perforations.
  • This approach offers improved healing rates compared to patching alone.
  • Further research with larger cohorts and extended follow-up is recommended.