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Risk of Safety Events in Vitiligo Patients: A Retrospective Real-World Data Study in the US
Kennedy Cook1, Nada M Elbuluk2, Roni Adiri3
1Pfizer Inc, New York, New York, USA.
The Journal of Dermatology
|April 6, 2026
Summary
Patients with vitiligo experience higher rates of autoimmune conditions, infections, and hearing loss compared to controls. Vitiligo prevalence is also higher in Asian and Hispanic populations.
Area of Science:
- Dermatology
- Epidemiology
- Pharmacovigilance
Background:
- Vitiligo is a chronic autoimmune skin condition.
- Evolving treatments necessitate safety assessments.
- Understanding vitiligo's comorbidities and risks is crucial.
Purpose of the Study:
- To evaluate patient demographics, comorbidities, and medication histories in vitiligo patients.
- To determine vitiligo prevalence and incidence across demographics.
- To assess safety events following vitiligo diagnosis.
Main Methods:
- Retrospective cohort study using US electronic health records (Jan 2016-Sep 2023).
- Included 15,047 vitiligo patients and 75,231 matched controls (age ≥12 years).
- Compared baseline characteristics and post-diagnosis event incidence rates.
Main Results:
- Vitiligo patients had higher baseline rates of autoimmune diseases, infections, and hearing loss.
- Post-diagnosis, increased incidence of autoimmune conditions, infections, hearing events, and skin cancer observed.
- Vitiligo incidence and prevalence were numerically higher in Asian and Hispanic populations.
Conclusions:
- Vitiligo is associated with a significant burden of comorbidities and safety events.
- Findings inform clinical management and therapeutic strategies for vitiligo.
- Further research is needed due to dataset limitations.
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