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Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
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Non-Catalyzed Cascade Double Imination Reaction of 2‑Fluoro-alk-3-yn-1-ones: Sustainable Synthesis of
Trevor L Olson1, Ariela W Kaspi-Kaneti1, Adrian Zając1
1Department of Chemistry, Oakland University, 146 Library Drive, Rochester, Michigan 48309-4479, United States.
Abstract:
The cascade reactions of 2-fluoroalk-3-yn-1-ones with o-phenylenediamines provide an effective synthetic method with high atom economy for the preparation of diversely substituted 3-fluoro-3H-benzo-[b]-[1,4]-diazepines (52-81%). This noncatalytic and sustainable process embraces formal hydroamination and imination reactions, resulting in the formation of two CN and two C-H bonds. DFT modeling provided additional insight into the reaction's mechanism, favoring the pathway involving initial cyclization of nonconjugated enaminone, o-aminoanilino-2-fluorobut-3-en-1-one. The reaction may be diverted to the formation of conjugated enaminone (o-aminoanilino-2-fluorobut-2-en-1-one), whose presence was confirmed by 1H NMR. The conformational properties of the 7-membered ring were investigated by the 1H and 19F variable temperature NMR studies in solution and by the X-ray structure determination of 3-fluoro-4-(4-methylbenzyl)-2-phenyl-3H-benzo-[b]-[1,4]-diazepine.
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