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Updated: Apr 7, 2026
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Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions
Published on: June 21, 2024
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Endometrial Microbiome and Implantation: From Basic Knowledge to Clinical Medicine
Daiki Hiratsuka1, Mitsunori Matsuo1, Yasushi Hirota1
1Department of Obstetrics and Gynecology, Graduate School of Medicine The University of Tokyo Tokyo Japan.
Reproductive Medicine and Biology
|April 6, 2026
Summary
The endometrial microbiome may influence recurrent implantation failure (RIF). A Lactobacillus-rich profile is linked to better outcomes, while other patterns suggest RIF. Targeted management shows potential but needs more research.
Area of Science:
- Reproductive Medicine
- Microbiome Research
- Infertility Studies
Background:
- Recurrent implantation failure (RIF) presents diagnostic and treatment challenges.
- Uterine factors are implicated, with recent focus on the endometrial microbiome.
- Vaginal dysbiosis is associated with negative reproductive outcomes.
Purpose of the Study:
- To review female reproductive tract microbiota.
- To summarize evidence on endometrial microbiome testing and management in infertility.
- To discuss the role of the endometrial microbiome in recurrent implantation failure.
Main Methods:
- Narrative review of clinical studies.
- Analysis of endometrial microbiome sequencing data.
- Evaluation of intervention studies for RIF management.
Main Results:
- Endometrial microbial signals are detectable but challenging to interpret due to low biomass and contamination.
- A Lactobacillus-enriched endometrial profile correlates with favorable pregnancy outcomes.
- Non-Lactobacillus-dominant patterns are more common in RIF, though results vary.
Conclusions:
- Evidence on the endometrial microbiome in infertility is evolving.
- Standardized methods for sampling and analysis are crucial for reliable interpretation.
- Further research with standardized protocols and real-world evaluations is needed.
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