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Updated: Apr 7, 2026
07:52
A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
Published on: April 9, 2019
9.3K
Blood-Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems
Yanan He1, Mengyao Qu1, Lu Yu1
1Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital Beijing China.
Medcomm
|April 6, 2026
Summary
The blood-brain barrier (BBB) protects the brain but hinders drug delivery. This review explores innovative strategies to overcome BBB challenges for treating neurological disorders.
Area of Science:
- Neuroscience
- Pharmacology
- Biotechnology
Background:
- The blood-brain barrier (BBB) is a critical neurovascular interface.
- It protects the central nervous system but impedes therapeutic access.
- BBB dysfunction is linked to major neurological diseases.
Purpose of the Study:
- To review BBB structure, function, and role in disease.
- To evaluate novel drug delivery strategies for brain disorders.
- To identify future research directions for BBB therapeutics.
Main Methods:
- Systematic examination of BBB organization and function.
- Analysis of passive and active drug targeting approaches.
- Evaluation of stimuli-responsive systems and nanoplatforms.
Main Results:
- BBB restricts over 98% of small molecules and nearly all large molecules.
- BBB dysfunction is implicated in stroke, Alzheimer's, Parkinson's, MS, and brain tumors.
- Various strategies show promise for enhancing brain drug delivery.
Conclusions:
- Overcoming the BBB is crucial for treating neurological diseases.
- Innovative approaches like nanoplatforms and focused ultrasound offer potential.
- Further research and clinical translation are needed for next-generation therapeutics.
Keywords:
blood–brain barrierdrug delivery systemsischemic strokenanoparticlesneurological diseasesneurovascular unittargeted therapyMore Related Videos
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