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Updated: Apr 7, 2026
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Effect of humidification intervention combined with cluster nursing on ventilator-associated pneumonia in ICU
Ying Liu1, Juan Liu1, Danfeng Zhang2
1Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China.
Background:
Ventilator-associated pneumonia (VAP) is a serious complication in mechanically ventilated patients, increasing morbidity, mortality, and antibiotic use. Although cluster nursing and humidification methods independently reduce VAP risk, their combined effect has not been rigorously evaluated.
Objective:
To determine whether combining dual humidification (heated humidifier plus heat-and-moisture exchanger) with a structured cluster nursing bundle reduces VAP incidence in Intensive Care Unit (ICU) patients. Methods: In this single-center cross-sectional observational study, 240 adult ICU patients expected to require ventilation for >48 h were observed under either enhanced care (dual humidification plus cluster nursing) or standard care. The cluster nursing bundle included head-of-bed elevation (30-45°), chlorhexidine oral care every 4 h, daily sedation breaks with weaning assessment, subglottic suctioning, enteral nutrition with prophylaxis, thrombosis prevention, and strict hand hygiene. The primary outcome was VAP incidence defined by CDC/NHSN criteria. Secondary outcomes included ventilator duration, ICU length of stay, antibiotic use, and mortality.
Results:
Ventilator-associated pneumonia incidence was significantly lower in the enhanced care cohort (10.0%) compared with standard care (30.0%) (p < 0.001), representing a 67% relative risk reduction (number-needed-to-treat = 5). Enhanced care patients had shorter ventilation duration (7.4 vs. 9.1 days, p = 0.003), shorter ICU stays (10 vs. 13 days, p = 0.01), fewer antibiotic days (6.8 vs. 10.7, p < 0.001), and delayed VAP onset (7.5 vs. 5.0 days, p = 0.04). Mortality was lower (18.3% vs. 25.8%) but not statistically significant. No tube occlusions or adverse respiratory events occurred.
Conclusion:
A dual humidification strategy combined with a high-compliance cluster nursing bundle significantly reduced VAP incidence and improved ICU outcomes. This cost-effective approach supports implementation to enhance patient safety and reduce antimicrobial resistance.
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