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Updated: Apr 7, 2026
Synovial Fluid Analysis to Identify Osteoarthritis
Published on: October 20, 2022
Interleukin-6 as a Marker of Joint Damage in Osteoarthritis: A Study of Its Pro-inflammatory Impacts
Dwitya Elvira1, Dela Hangri Jalmas2
1Allergy and Clinical Immunology Division, Internal Medicine Department, Medical Faculty of Universitas Andalas/M. Djamil Hospital, Padang, Indonesia.
Background:
Osteoarthritis (OA) is a degenerative joint disease characterized by a complex pathophysiology involving inflammatory biomarkers.
Objectives:
The current study aimed to investigate the correlation between interleukin-6 (IL-6) serum levels and joint space narrowing (JSN) in patients with knee OA.
Design:
A total of 46 patients clinically diagnosed with knee OA were included in this study.
Methods:
Joint space narrowing was measured using radiographic examinations, whereas blood serum levels of IL-6 were quantified using enzyme-linked immunosorbent assay. Statistical analysis was performed to determine the relationship between IL-6 and JSN.
Results:
The average level of IL-6 was 117.61 (67.05) ng/mL, with JSN measurement of 1.76 (1.31) mm. An inverse correlation found between IL-6 levels and the size of the gap joints in patients with knee OA (r = -.298; P = .044).
Conclusion:
An inverse correlation exists between IL-6 levels and joint impairment in knee OA, suggesting that inflammation plays a crucial role in the progression of the disease.
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