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Updated: Apr 7, 2026
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Interplay between genetically predicted gut microbiota and chronic apical periodontitis: a Mendelian randomization
Lijing Zhu1, Yu Xie2, Xuechao Yang1
1Department of Endodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, People's Republic of China.
Journal of Oral Microbiology
|April 6, 2026
Summary
This study used Mendelian randomization to investigate the gut microbiota
Area of Science:
- Microbiome research
- Genetics
- Dental medicine
Background:
- The causal role of gut microbiota in chronic apical periodontitis (CAP) is not fully understood.
- Investigating the gut microbiome's influence on CAP is crucial for understanding disease pathogenesis.
Purpose of the Study:
- To assess the potential causal effect of gut microbiota on chronic apical periodontitis (CAP) risk.
- To explore the genetic associations between gut microbial composition and CAP susceptibility.
Main Methods:
- A two-sample Mendelian randomization (MR) analysis was employed.
- Gut microbiota data from MiBioGen consortium GWAS and CAP data from FinnGen project were utilized.
- Inverse variance-weighted method and sensitivity analyses were performed to ensure robustness.
Main Results:
- Two microbial taxa, Lachnospiraceae FCS020 group and Ruminococcus2, showed a positive causal effect on CAP risk.
- Escherichia-Shigella exhibited an inverse genetic association with CAP risk.
- Sensitivity analyses confirmed the stability and consistency of the findings.
Conclusions:
- This MR analysis provides evidence for a genetic relationship between gut microbiota and CAP susceptibility.
- The findings suggest that alterations in gut microbiota composition may be genetically associated with CAP risk.
- This research enhances understanding of microbial involvement in CAP.
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