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Updated: Apr 7, 2026

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments
Published on: May 26, 2019
New-generation Indian Linear Accelerator: Validation of Specifications and Comparative Analysis.
Ramamoorthy Ravichandran1, Tarani Mondal1, Tamilarasan Mani2
1Department of Radiation Oncology, Cachar Cancer Hospital and Research Centre, Medical Physics Unit, Silchar Assam, India.
India
Area of Science:
- Medical Physics
- Radiation Oncology
- Biomedical Engineering
Background:
- Radiotherapy (RT) is essential for cancer treatment, with India facing a significant shortage of RT machines.
- The "Make in India" initiative aims to develop indigenous linear accelerators to address this gap.
- A new low-energy (6 MV) linear accelerator has been developed and installed in Indian oncology centers.
Purpose of the Study:
- To evaluate the performance and efficacy of the indigenous Siddharth II© linear accelerator.
- To compare its radiation delivery parameters with a well-established imported model (Varian TrueBeam©).
- To assess its suitability for clinical use in India.
Main Methods:
- Performance specifications and beam characteristics of five Siddharth II© linacs were measured during commissioning and type approval.
- Radiation safety parameters were assessed.
- Data was compared with measured 6 MV photon values from an imported Varian TrueBeam© model.
Main Results:
- The indigenous 6 MV linear accelerator (Siddharth II©) demonstrated adequate design and comparable radiation beam delivery to imported models.
- All radiation safety parameters met international standards and were on par with imported machines.
- Five linacs were installed and evaluated over a 2-year period.
Conclusions:
- The Siddharth II© linac meets clinical requirements and performs comparably to imported linear accelerators.
- This indigenous technology represents a significant step towards self-reliance in cancer treatment infrastructure.
- It promises wider accessibility and affordability of radiotherapy for Indian patients.
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