Linezolid-Associated Non-convulsive Status Epilepticus: A Case Report

Neural, metabolic, and myelosuppressive side effects can occur upon administration of linezolid (LNZ), which is an antibiotic that can cause seizures through multiple mechanisms. Here, we describe the case of a 77-year-old woman who initially presented with a subdural hematoma (SDH). She subsequently developed non-convulsive status epilepticus (NCSE), a category of seizure that can occur secondary to antibiotic use. These episodes persisted despite being treated by multiple anti-epileptic medications, but resolved upon cessation of linezolid. This case is important because it highlights how the appropriate use of a drug can still cause a serious neurological side effect that can negatively impact patient outcomes.