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Updated: Apr 7, 2026

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CD147: a critical factor in normal and pathological pregnancies.

Hangyu Sun1, Jingran Gao1, Shuqi Yang1

  • 1Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Shanghai, China.

Frontiers in Medicine
|April 6, 2026
PubMed
Summary

CD147 (Basigin/EMMPRIN) is crucial for normal pregnancy, aiding implantation and placental development. Aberrant CD147 levels are linked to pregnancy complications like pre-eclampsia and fetal growth restriction, suggesting its potential as a biomarker.

Keywords:
CD147maternal-fetal interfaceplacentapregnancytrophoblast

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Area of Science:

  • Reproductive biology
  • Molecular and cellular biology
  • Immunology

Background:

  • CD147 (Basigin/EMMPRIN) is a transmembrane glycoprotein with known roles in cancer.
  • Its specific functions during human pregnancy are not fully understood.
  • Understanding CD147's role is vital for addressing pregnancy complications.

Purpose of the Study:

  • To systematically review the expression patterns and functions of CD147 in normal and pathological pregnancies.
  • To elucidate the mechanisms by which CD147 influences pregnancy outcomes.
  • To highlight CD147's potential as a diagnostic biomarker and therapeutic target in obstetrics.

Main Methods:

  • Literature review of studies on CD147 expression and function in pregnancy.
  • Analysis of CD147's role in key pregnancy processes like implantation, placental development, and angiogenesis.
  • Correlation of CD147 expression levels with various pregnancy pathologies.

Main Results:

  • CD147 is essential for normal pregnancy, regulating matrix metalloproteinases (MMPs), angiogenesis, immune micro-environment, and placental metabolism.
  • Down-regulation of CD147 is associated with pre-eclampsia, recurrent implantation failure, and fetal growth restriction.
  • Up-regulation of CD147 is implicated in gestational choriocarcinoma and placenta accreta spectrum.

Conclusions:

  • CD147 exhibits a "dual regulatory" role in pregnancy, essential for normal development but linked to pathologies when dysregulated.
  • CD147 presents significant potential as a biomarker for diagnosing and monitoring pregnancy complications.
  • Targeting CD147 may offer novel therapeutic strategies for improving pregnancy outcomes.