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Updated: Apr 7, 2026
Quantifying the Binding Interactions Between CuII and Peptide Residues in the Presence and Absence of Chromophores
Published on: April 5, 2022
A dual-signals peptide-based probe for fluorometric and colorimetric detection of copper(II) ions and glyphosate in
Yi Ren1, Mengying Jia1, Shiyi Xiong1
1Precise Synthesis and Function Development Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Shida Road 1#, Nanchong 637009, PR China.
Abstract:
A new dual-signals peptide-based probe FAHK was rationally designed and successfully synthesized for sequential detection of Cu2+ and glyphosate through fluorescence and colorimetric sensing method. The limit of detections (LODs) for Cu2+ and glyphosate were calculated to be 49.7 nM and 66.3 nM, respectively. Additionally, FAHK not only demonstrated excellent accuracy in the determination of real food, water and vegetables samples, but also was applied for fluorescence imaging Cu2+ and glyphosate in two biological systems. Besides, test strips experiments showed that FAHK has extraordinary potential in environmental monitoring and food analysis applications. Meanwhile, we explored the application of FAHK in molecular logic gates, and a visual portable sensing platform was established via the smartphone color picker App system, and successfully achieving semi-quantitative analysis of Cu2+ and glyphosate. More importantly, FAHK has successfully achieved the detection of glyphosate residues on six food surfaces and soil sample with satisfactory results.
