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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
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Related Experiment Video

Updated: Apr 7, 2026

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform
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ASTROREPOMICS: A curated transcriptomic database for reproductive biology in space.

Chun-Fan Lung1, Kun-I Lin2,3, Yi-Chiung Hsu1,4,5,6

  • 1Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.

Iscience
|April 6, 2026
PubMed
Summary

Spaceflight impacts reproductive health. A new platform, ASTROREPOMICS, integrates transcriptomic data to analyze these effects across species, aiding fertility research for space exploration.

Keywords:
omicsspace sciences

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Area of Science:

  • Space biology
  • Reproductive science
  • Genomics

Background:

  • Spaceflight poses significant physiological stress on reproductive systems.
  • Existing transcriptomic data related to spaceflight's reproductive effects are fragmented across various repositories.
  • A unified resource is needed for comprehensive analysis and understanding.

Purpose of the Study:

  • To develop ASTROREPOMICS, a web-based platform integrating multiple transcriptomic datasets.
  • To enable reproducible cross-study and cross-species analyses of reproductive health in space.
  • To facilitate hypothesis generation for space-related reproductive research.

Main Methods:

  • Integrated 17 normalized and batch-corrected transcriptomic datasets.
  • Utilized standardized metadata and an intuitive user interface for data accessibility.
  • Performed cross-species comparative analyses and intersected differential gene expression (DEG) assessments.

Main Results:

  • ASTROREPOMICS provides a centralized, accessible resource for spaceflight reproductive transcriptomics.
  • Analysis revealed suppressed RNA splicing and protein processing in irradiated mouse sperm, with activated interferon and GPCR pathways.
  • Identified conserved signatures in RNA metabolism, cytokine signaling, and angiogenesis between irradiated rat mammary tissue and microgravity-exposed zebrafish embryos.

Conclusions:

  • ASTROREPOMICS consolidates dispersed data, offering tailored analytical capabilities for reproductive health in space.
  • The platform strengthens research infrastructure for safeguarding fertility during deep-space exploration.
  • Findings highlight conserved molecular responses to spaceflight stressors across different species and tissues.