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Related Experiment Video

Updated: Apr 7, 2026

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
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Mastoid Obliteration Using Granules of S53p4 Bioactive Glass: Systematic Review and Meta-Analysis.

Luca Canali1,2,3, Matteo Di Bari1,4, Sean C Sheppard1

  • 1Department of Otorhinolaryngology, Hôpital Pitié-Salpêtrière, AP-HP, Sorbonne Université, Paris, France.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|April 6, 2026
PubMed
Summary

S53P4 bioactive glass (BAG) granules are safe for mastoid obliteration, showing low complication rates and good inner-ear tolerance. Further studies are recommended to confirm these findings for otologic surgery.

Keywords:
biosynthetic materialbone substitutescholesteatomachronic otitistympanoplasty

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Area of Science:

  • Otolaryngology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Mastoid obliteration is a surgical technique used in otologic procedures.
  • Bioactive glass (BAG) materials, such as S53P4, are being explored for their potential in bone regeneration and wound healing.
  • Evaluating the safety and efficacy of novel biomaterials in otologic surgery is crucial.

Purpose of the Study:

  • To systematically review and meta-analyze the tolerance and postoperative complication rates of S53P4 BAG granules in mastoid obliteration.
  • To assess the audiological outcomes following mastoid obliteration with S53P4 BAG.

Main Methods:

  • Systematic literature search conducted across major databases (PubMed, Scopus, Web of Science, Cochrane Library).
  • Meta-analysis performed following PRISMA guidelines.
  • Data extraction focused on complication rates and audiological outcomes.

Main Results:

  • Included 12 studies with 583 patients; mean follow-up of 28.8 months.
  • Pooled complication rates: 16% for otorrhea, 2% for surgical wound infection, 1% for BAG granule extrusion.
  • Bone conduction remained stable postoperatively, indicating good inner-ear tolerance.

Conclusions:

  • S53P4 BAG granules demonstrate a favorable safety profile for mastoid obliteration.
  • The material exhibits a low incidence of postoperative complications and good inner-ear tolerance.
  • Multicenter prospective studies are recommended to validate these findings.