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Updated: Apr 7, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
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Angiocentric T-cell lymphoma in a cat.

Kaitlyn H Krebs1, Natalia J Strandberg1, Francisco R Carvallo-Chaigneau1

  • 1Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|April 6, 2026
PubMed
Summary

Angiocentric T-cell lymphoma, a rare cancer, can affect multiple organs in cats. This lymphoma involves neoplastic cells surrounding blood vessels, leading to severe symptoms and organ dysfunction.

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Area of Science:

  • Veterinary Medicine
  • Oncology
  • Pathology

Background:

  • A 15-year-old domestic shorthair cat presented with lethargy, inappetence, and weight loss.
  • Clinical findings included anemia, abnormal lymphocytes, and enlarged spleen and lymph nodes.

Purpose of the Study:

  • To diagnose and characterize a rare form of lymphoma in a feline patient.
  • To investigate the cause of severe gastrointestinal signs and disseminated vasculopathy.

Main Methods:

  • Cytologic evaluation of peritoneal fluid, spleen, and lymph node aspirates.
  • Histological examination of multiple organs.
  • Immunohistochemistry (CD3) and PCR for T-cell receptor gene rearrangement.

Main Results:

Keywords:
T-cell lymphomaangiocentricfelineintestinal pseudo-obstructionneoplasia

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  • Neoplastic round cells centered on blood vessels in lungs, liver, spleen, kidneys, and brain.
  • Immunohistochemistry confirmed CD3-positive cells, and PCR revealed a clonal T-cell receptor gene.
  • Diagnosis of angiocentric T-cell lymphoma was established.

Conclusions:

  • Angiocentric T-cell lymphoma should be considered in cats with disseminated vasculopathy and gastrointestinal signs.
  • Neoplastic infiltration of the myenteric plexus likely caused intestinal pseudo-obstruction.
  • This case highlights a rare presentation of lymphoma in a feline patient.