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Angiocentric T-cell lymphoma in a cat
Kaitlyn H Krebs1, Natalia J Strandberg1, Francisco R Carvallo-Chaigneau1
1Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.
Summary
Angiocentric T-cell lymphoma, a rare cancer, can affect multiple organs in cats. This lymphoma involves neoplastic cells surrounding blood vessels, leading to severe symptoms and organ dysfunction.
Area of Science:
- Veterinary Medicine
- Oncology
- Pathology
Background:
- A 15-year-old domestic shorthair cat presented with lethargy, inappetence, and weight loss.
- Clinical findings included anemia, abnormal lymphocytes, and enlarged spleen and lymph nodes.
Purpose of the Study:
- To diagnose and characterize a rare form of lymphoma in a feline patient.
- To investigate the cause of severe gastrointestinal signs and disseminated vasculopathy.
Main Methods:
- Cytologic evaluation of peritoneal fluid, spleen, and lymph node aspirates.
- Histological examination of multiple organs.
- Immunohistochemistry (CD3) and PCR for T-cell receptor gene rearrangement.
Main Results:
- Neoplastic round cells centered on blood vessels in lungs, liver, spleen, kidneys, and brain.
- Immunohistochemistry confirmed CD3-positive cells, and PCR revealed a clonal T-cell receptor gene.
- Diagnosis of angiocentric T-cell lymphoma was established.
Conclusions:
- Angiocentric T-cell lymphoma should be considered in cats with disseminated vasculopathy and gastrointestinal signs.
- Neoplastic infiltration of the myenteric plexus likely caused intestinal pseudo-obstruction.
- This case highlights a rare presentation of lymphoma in a feline patient.
